Conferences

Program

Chemical Cross-linking and Covalent Labeling: From Proteins to Cellular Networks

January 24 - 27, 2019
St. Petersburg, FL

Organizers

  • Lan Huang, University of California, Irvine
  • Andrea Sinz, Martin-Luther University Halle-Wittenberg
  • Richard Vachet, University of Massachusetts

Keynote Lecture Speakers

  • Ruedi Aebersold,ETH
  • Brian Chait, Rockefeller University
  • Carol Robinson, Oxford University

Thursday, January 24, 2019

6:00-7:00 pm, Registration

7:00-7:05 pm, Opening Remarks: Andrea Sinz, Richard Vachet & Lan Huang

7:05-8:05 pm, Plenary Lecture: Carol Robinson, University of Oxford

8:05-10:00 pm, Reception

Friday, January 25, 2019

8:30-11:00 am, Developing Cross-linking Mass Spectrometry to Delineate Protein Structures
Each talk is 30' followed by several minutes for Q&A.

  • "Protein Structure Prediction by the Combined Approach of Short Distance Crosslinking and Discret Molecular Dynamics"; Christoph Borchers, University of Victoria, Canada
  • "Improving Mass Spectrometry Analysis of Protein Structures with Arginine-Selective Chemical Cross-linkers"; Meng-Qiu Dong, National Institute of Biological Sciences, China
  • "Cross-linking/Mass Spectrometry Workflows Based on MS-Cleavable Cross-Linkers and the MeroX Software for Studying Protein Structures and Protein-Protein Interactions"; Andrea Sinz, Martin Luther University Halle-Wittenberg

10:00-10:15 am, Coffee Break

10:15-11:45 am, Developing Cross-linking Mass Spectrometry to Delineate protein Structures
Each talk is 30' followed by several minutes for Q&A.

  • Lan Huang, University of California, Irvine
  • "Kinetochore Assembly and Function: Insights by Chemical Crosslinking and Mass Spectrometry"; Franz Herzog, Ludwig-Maximilians-Universität München
  • Martin Beck, EMBL Heidelberg

11:45 am-12:00 pm, Group Photo

12:00-1:15 pm, Lunch on your own

1:15-3:15 pm, Oxidative Labeling
Each talk is 30' followed by several minutes of Q&A.

  • Michael Gross, Washington University
  • "Structure and Dynamics of Macromolecules Using Footprinting"; Mark Chance, Case Western Reserve University
  • "Reproducibility and Robustness in FPOP:  the Need for Community Standards for Radical Dosimetry"; Josh Sharp, University of Mississippi
  • "Functional Implications of Protein Oxidation: Turning Cytochrome C into an Apoptotic Peroxidase"; Lars Konermann, Western University, Canada

3:15-7:00 pm, Free Time

7:00-7:45 pm, Keynote Lecture: "Surveying and Mapping Macromolecular Cellular Terrains"; Brian Chait, Rockefeller University

7:45-8:00 pm, Highlighted poster presentations

8:30-10:00 pm, Poster Session I

Saturday, January 26, 2019

8:30-10:15 am, Software Development and Structural Modeling
Each talk is 30' followed by several minutes for Q&A.

  • "Incorporating XlinkX into Integrative Structural Biology"; Albert Heck, University of Utrecht
  • "The MaxQuant Software for Cross-Linking/Mass Spectrometry"; Jürgen Cox, MPI Martinsried
  • "Reliable Identification of Cross-Links with Non-Cleavable Linkers", Robert Chalkley, University of California, San Francisco
  • "Macromolecular Structure and Dymamics Based on Cross-Links"; Dina Schneidman, Hebrew University

10:30-10:45 am, Coffee Break

10:45-11:45 am, Hot Topic Talk

12:00-1:15 pm, Lunch on your own

1:00-2:30 pm, in vivo Labeling and Analysis of Cellular Networks
Each talk is 30' followed by several minutes for Q&A.

  • "Quantitative Interactome Dynamics: A Look under the Hood"; Jim Bruce, University of Washington, Seattle
  • "In-Cell Footprinting for Proteome-Wide Structural Biology"; Lisa Jones, University of Maryland
  • Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

2:30-3:00 pm, Hot Topic Talk

3:00-7:00 pm, Free Time

7:00-8:00 pm, Hot Topics/Poster Presentations:

7:00-7:30 pm, Hot topic presentations (x2)

7:30-8:00 pm, Highlighted poster presentations

8:30-10:00 pm, Poster Session II

Sunday, January 27, 2019

8:30-10:00 am, Defining Protein Aggregates/Complexes
Each talk is 30' followed by several minutes for Q&A.

  • "Insight into beta-2-Microglobulin Amyloid Formation and Inhibition Using Covalent Labeling Mass Spectrometry"; Richard Vachet, University of Massachusetts
  • "Diazirine-Based Reagents for Structural Mass Spectrometry of Complex Systems"; David Schriemer, University of Calgary, Canada
  • "Methods and Applications for the Thermodynamic Analysis of Protein-Ligand Complexes on the Proteomic Scale"; Michael Fitzgerald, Duke University

10:00-10:15 am, Coffee Break

10:15-11:15 am, Defining Protein Aggregates/Complexes (Continued)
Each talk is 30' followed by several minutes for Q&A.

  • "Structural Basis of Cullin-RING E3 Ligase Regulation by the COP9 Signalosome Using Integrative Mass Spectrometry"; Argyris Politis, King's College London
  • Vicki Wysocki, Ohio State University

11:15 am -12:15 pm, Plenary Lecture: "Towards the Modular Proteotype", Ruedi Aebersold, ETH

12:15-12:30 pm, Closing Remarks
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