John B. Fenn Distinguished Contribution

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The ASMS Award for Distinguished Contribution in Mass Spectrometry is named to honor the memory of John B. Fenn who shared the 2002  Nobel Prize for the development of electrospray Ionization. John joined ASMS in 1986 and remained an active member until his passing in 2010. 

The John B. Fenn Award for a Distinguished Contribution in Mass Spectrometry recognizes a focused or singular achievement in fundamental or applied mass spectrometry in contrast to awards that recognize lifetime  achievement. Eligibility is restricted to members of ASMS. Nominations will be held for three years. The award is conferred at the ASMS Annual Conference with the presentation of a $10,000 cash award, a recognition plaque, and the award lecture.

Nominations are due November 30.  Nomination Form (PDF fill-in form).

Michael L. Gross, 2020 Recipient

Distinguished-GrossDr. Michael L. Gross is the recipient of the 2020 ASMS John B. Fenn Award for a Distinguished Contribution in Mass Spectrometry, for innovative and integrative MS-based footprinting for structural proteomics. The development of Fast Photochemical Oxidation of Proteins (FPOP), whereby covalent modifications of proteins can occur with hydroxyl radicals on the microsecond time scale, enables the study of protein conformation, folding, aggregation, and the identification of extracellular domains.

Additionally, Dr. Gross combined MS with hydrogen-deuterium exchange (HDX) as a complement to FPOP for the determination of protein affinity, and he has developed protein chemistry methods for glycine ethyl ester (GEE) footprinting of side chains of aspartate and glutamate.  Implementing these methods in combination has allowed significant insights to be gained with regard to many proteins with important therapeutic and clinical implications.  His integrative approach is setting the standard for structural proteomics, as evidenced by its wide application in the pharmaceutical industry for the characterization of therapeutic proteins.

Dr. Gross is Professor of Chemistry and of Immunology and Internal Medicine (School of Medicine), Washington University in St. Louis.