ASMS News & Views

Jan 06, 2016

2014 ASMS Research Award Winner Article ‘Highlight’

The ASMS annually presents two Research Awards to academic scientists within four years of joining the tenure track faculty or equivalent in a North American university. The purpose of these awards, fully sponsored by Thermo Scientific and Waters Corporation, is to promote academic research in mass spectrometry by young scientists.

In this month’s issue of JASMS, we are pleased to highlight a research article by one of the 2014 ASMS Research Award winners, Dr. Zhibo Yang, Assistant Professor in the Department of Chemistry and Biochemistry at the University of Oklahoma, and co-authored by Wei Rao, Ning Pan and Xiang Tian from Dr. Yang’s laboratory. The article, entitled “High-Resolution Ambient MS Imaging of Negative Ions in Positive Ion Mode: Using Dicationic Reagents with the Single-Probe”, was supported by Dr. Yang’s ASMS Research Award. This article reports the use of the Single-probe, a miniaturized sampling device utilizing in situ surface microextraction for ambient mass spectrometry (MS) analysis developed in the Yang lab, for high spatial resolution (~17 μm) MS imaging (MSI) of negatively charged species extracted from mouse brain tissue sections in positive ionization mode, after the addition of dicationic compounds to the sampling solvent. The ion intensities for the dicationic adducts were found to be higher in positive ionization mode than those observed for the analytes in negative ionization mode, and importantly, facilitated the detection of a number of compounds that were not detected under negative ionization mode conditions.

Dr Yang obtained his B.S. in Geochemistry (1997) and an M.S. degree in Physical Chemistry (2000) from the University of Science and Technology of China. In 2005, he received his Ph.D. degree in Physical Chemistry under the supervision of Prof. Mary T. Rodgers at Wayne State University. He then conducted postdoctoral research with Dr. Julia Laskin at Pacific Northwest National Laboratory (2005–2008) and Prof. Veronica M. Bierbaum at the University of Colorado, Boulder (2008–2012) prior to starting his independent career at the University of Oklahoma. Dr. Yang’s current research is broadly focused on the development and application of novel mass spectrometry techniques for single cell analysis and tissue imaging. In addition to the ASMS Research Award, this research is supported by funding from the Oklahoma Center for the Advancement of Science and Technology, and the National Institutes of Health. To date, Dr Yang has published 50 peer-reviewed manuscripts, and the results from his research have been reported in C&E News, and Chemistry World.