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Sample Preparation for Analysis of Real-World Samples by Mass Spectrometry: The Common Denominator for Quality Data

November 3-4, 2016

Sheraton Inner Harbor Hotel
Baltimore, MD


Jack Henion, Advion
Russell Grant, LabCorp

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Workshop Description

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To-date even the most sophisticated as well as the simplest analyses by mass spectrometry generally benefit or are optimized with some degree of sample preparation.  Recent successes of MALDI for tissue imaging and the recently introduced ambient ionization techniques (DART, DESI, ASAP, etc.) provide some ability to analyze untreated complicated samples. Often the more sophisticated information actually needed (regulated bioanalysis, clean CID mass spectra for interpretation of unknown structures, and multi-component mixtures with wide differences in concentration) enjoy significant benefits from selective sample preparation strategies. All of these applications tend to be compared with the now well established ionization techniques of electrospray (ESI) and atmospheric pressure chemical ionization (APCI) which uniquely enjoy convenient coupling with HPLC.

In contrast recent new ionization techniques including DART, DESI, ASAP, LAESI, Paper Spray, etc. as well as cellulose substrates for dried blood spot (DBS) sample collection suggest that little or no sample preparation or coupling with HPLC may be required.  These claims tend to confuse new practitioners of mass spectrometry in part because ideally this is what they want to hear in spite of often sub optimal success.  In actuality it depends upon the analytical questions being asked and the mass spectrometry techniques being employed whether sample preparation is required.

This planned ASMS Workshop entitled Sample Preparation for Analysis of Real-World Samples by Mass Spectrometry: The Common Denominator for Quality Data is designed to provide an honest, realistic update on the issues pertaining to the successful acquisition of meaningful data which answers important questions from mass spectrometric analysis of a wide variety of different sample types and applications.  The workshop also is organized with leading practitioners who have introduced or employed innovative and emerging approaches that provide improvements as well as automation beyond established techniques.

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