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| The Biemann Medal
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2009 Recipient: Neil Kelleher
Top-down proteomics is now a household word among ASMS members, and this is largely due to Neil L. Kelleher, who started top-down analysis and has vigorously promoted this technology starting as a graduate student and continuing today. Unlike the bottom-up approach that starts with protein fragments, top-down proteomics preserves information concerning protein isoforms and the interplay between posttranslational modifications by isolating and fragmenting whole proteins in the gas phase. The analytical software he has developed, ProSight PTM, provides the charge- and isotope-deconvolution needed for top-down proteomics data and is used by over 450 laboratories worldwide. Dr. Kelleher has applied top-down analysis to a number of important biological systems, such as the protein component of human chromatic and determination of the post-translational dynamics of histone H4 through the cell cycle. His laboratory is a major driving force in the extension of tandem mass spectrometry to high mass ions, generating over 130 papers in peer-reviewed journals and already leading to a number of major awards.
Neil Kelleher is Professor of Chemistry at the University of Illinois (Urbana-Champaign). |
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