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Ileana Cristea performed her graduate research at the Michael Barber Center for Mass Spectrometry, University of Manchester, U.K., under the supervision of Simon Gaskell, and at the Toxicology Research & Development Department at GlaxoSmithKline, U.K. She pursued her postdoctoral work in the mass spectrometry laboratory of Brian Chait at The Rockefeller University. She is currently Assistant Professor in the Department of Molecular Biology at Princeton University.
The research of the Cristea laboratory is at the interface between mass spectrometry and virology. Her goal is to build an understanding of viral infection from a proteomics perspective. Over the last years she advanced current proteomics approaches in their ability to access transient cellular events, developing methods for characterizing and quantifying virus-host protein interactions during viral infection. Her laboratory utilizes a multi-disciplinary approach that integrates modern mass spectrometry with genetics, microscopy, bioinformatics, and virology, generating a systems biology view of infection. These approaches allowed her group to bridge developments in mass spectrometry to critical findings in biology, and identify mechanisms utilized by viruses to manipulate host cell processes at different stages of the virus life cycle.
Dr. Cristea contributes to the Education Committees of US-HUPO (2011-present) and ASMS (2008-2010), and the Editorial Boards of Molecular & Cellular Proteomics and Journal of Neuroimmune Pharmacology. A member of ASMS since 2000, she has chaired ASMS oral sessions and has served on the program review committee. Her teaching activities have included a section of the Cold Spring Harbor Proteomics Course focused on protein complexes (2006-2011), in 2011 becoming a main instructor. She has taught related workshops at ASMS, HUPO World Congress, AOHUPO, and ABRF, and will lead a new protein interaction course at US-HUPO (2012). She was recently selected by Francis Collins as one of 24 participants for the NIH workshop “Innovation Brainstorm: Transforming Discovery into Impact” (2011). Dr. Cristea is the recipient of numerous awards, including the Bordoli Prize from the British Mass Spectrometry Society (2001), NIDA Avant-Garde Award for HIV/AIDS Research (2008), and Human Frontiers Science Program Young Investigator Award (2009).
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Neil Kelleher completed joint graduate work with Tadhg Begley and Fred McLafferty at Cornell University in 1997, when he moved to the laboratory of Christopher Walsh at Harvard Medical School. This training in high performance mass spectrometry and enzymology explains much of the research performed by his independent laboratory over the last decade at the University of Illinois in Urbana-Champaign. In 2010 the Kelleher group relocated to Northwestern University where the three main sub-groups continue working in the areas of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin Biology. At Northwestern Neil is a professor in Molecular Biosciences, Chemistry and the Fienberg School of Medicine as well as the Director of the Proteomic Center of Excellence (PCE).
The core of the Kelleher team is built around expertise in complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and natural products research. The Kelleher group has a track record built up involving protein separations, mass spectrometric hardware, and success in software development to harness the value of complex data. The PCE is a collaborative research center focused on the qualitative and quantitative detection proteins in biological systems. The center implements known technologies for “Bottom Up” proteomics, but emphasizes the philosophy of ‘precision proteomics,’ using high performance mass spectrometry to achieve protein identifications with very high confidence. The Center also develops next-generation proteomics using intact proteins (i.e., the “Top Down” approach) and efficiently translates this frontier approach to Chicago-area scientists.
Dr. Kelleher has about 170 publications, carries an H-factor of ~45, and provides ProSight software via the web to over 800 labs around the world. He is a member of the American Chemical Society, the American Society for Biochemistry and Molecular Biology, the American Association for the Advancement of Science, the American Society of Mass Spectrometry and the Human Proteome Organization. Dr. Kelleher has served on multiple NIH study sections. He has also served as a judge for the Top 10 Innovations award (The Scientist Magazine, 2010) and currently serves on the Executive Advisory Board for the Human Proteome Organization (2011-2013).
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