|
B.S., Chemistry (University of Wisconsin-Madison); M.S., Ph.D., Physical Chemistry (Cornell University, Professor Paul Houston); Postdoctoral Fellow (Pacific Northwest National Laboratory, Dr. Richard D. Smith). Dr. Loo is currently a Research Biological Chemist in the Department of Biological Chemistry, David Geffen School of Medicine, UCLA. She is also a member of UCLA's Molecular Biology Institute and the Institute for Genomics and Proteomics. Dr. Loo has been actively engaged in biological mass spectrometry since the early 1990's, initially applying ion-ion and ion-molecule reactions with ESI to probe protein structure. In 1992, she moved to Ann Arbor, MI, to lead MS services at the University of Michigan Protein and Carbohydrate Structure Facility. In addition to collaborating with biomedical research scientists, she worked with Prof. Philip Andrews to develop the "virtual 2D gel" technique, a MALDI-MS-based gel-imaging method for profiling proteins. Moving to Pfizer Global Research in 1998, she worked closely with antibacterial and other therapeutic areas.
At UCLA, Dr. Loo engages in characterizing archaeal and bacterial proteomes, de novo sequencing, and elucidating the mechanism of increased charging for ESI (i.e., supercharging). These efforts resulted in 85 peer-reviewed publications and book chapters, and 110 presentations at conferences and institutions. Her research is supported by NIH and the US Department of Energy.
Dr. Loo has been an ASMS member since 1990, and twice she has participated on the ASMS Nominating Committee. She has also been active in the Association for Biomolecular Resource Facilities (ABRF) serving on numerous committees, including the Survey and MS Committees, and Chair of the Proteomic Standards Committee. She also serves on the Membership Committee of the international Human Proteome Organization (HUPO) and has organized and chaired many conference sessions, including ASMS, ABRF, FACSS, and the ASMS Asilomar Conference. Dr. Loo organized and participated as an instructor for a "De Novo Peptide Sequencing" course at the 2010 US HUPO conference. Dr. Loo has been on the Editorial Board of Analytical Chemistry (A-Page) and is currently on the Journal of Biomolecular Technology's board.
|
Ph.D. degree in Physical Chemistry (University of Zagreb, Croatia). Dr. Paša-Tolić conducted post-doctoral research at the National High Magnetic Field Lab in Florida (Dr. Alan Marshall) and Pacific Northwest National Laboratory (PNNL) in Richland, Washington (Dr. Richard Smith). Dr. Paša-Tolić is a staff scientist at PNNL and mass spectrometry lead at Environmental Molecular Sciences Laboratory (EMSL), a national user facility located at PNNL. At EMSL, she manages access and support for an international user base to state-of-the-art capability with over 30 mass spectrometers and a variety of commercial and custom LC systems.
Dr. Paša-Tolić has expertise with FTICR mass spectrometry ranging from fundamental aspects and design of new instrumentation to its application with different formats of high resolution bio-separations in biological and biomedical research. Her current research emphasis involves development and application of new tools to accurately quantify changes in protein abundance, specifically protein post-translational modifications, their coordination and dynamics (i.e., top-down mass spectrometry). She was among the first to use stable isotope labeling methods, now central to quantitative proteomics, to impart a specific isotope signature into proteins and was a key contributor in pioneering efforts of PNNL's high throughput accurate mass and time tag strategy for sensitive high-throughput proteomics. Her work has resulted in nearly 120 peer-reviewed publications and book chapters.
Dr. Paša-Tolić has been an active member of ASMS since 1994. She organized and chaired sessions on the application of mass spectrometry for characterizing proteomes at the intact protein level at ASMS Conferences in 2002 and 2004. She also served in various positions on the ASMS Sanibel Committee for three years (2006-9). She participated as an ad hoc reviewer for the NIH technology development and high-end instrumentation grant review committees and evaluated proposals for NCI and NSF. She has also served as a reviewer for a number of scientific journals, including JASMS, Analytical Chemistry, Proteomics, Molecular & Cellular Proteomics and Journal of Proteome Research.
|